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DNA Lesion Alters Global Conformational Dynamics of Y-family DNA Polymerase during Catalysis
A major product of oxidative damage to DNA, 8-oxo-7,8-dihydro-2′-deoxyguanine (8-oxoG), can lead to genomic mutations if it is bypassed unfaithfully by DNA polymerases in vivo. However, our pre-steady-state kinetic studies show that DNA polymerase IV (Dpo4), a prototype Y-family enzyme from Sulfolob...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3339956/ https://ncbi.nlm.nih.gov/pubmed/22362779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345835 |
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