Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase

Aminopeptidases are key enzymes involved in the regulation of signaling peptide activity. Here, we present a detailed biochemical and structural analysis of an evolutionary highly conserved aspartyl aminopeptidase called DNPEP. We show that this peptidase can cleave multiple physiologically relevant...

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Main Authors: Chen, Yuanyuan, Farquhar, Erik R., Chance, Mark R., Palczewski, Krzysztof, Kiser, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339940/
https://ncbi.nlm.nih.gov/pubmed/22356908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347518
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