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Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis
RPE65 is a key metalloenzyme responsible for maintaining visual function in vertebrates. Despite extensive research on this membrane-bound retinoid isomerase, fundamental questions regarding its enzymology remain unanswered. Here, we report the crystal structure of RPE65 in a membrane-like environme...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478654/ https://ncbi.nlm.nih.gov/pubmed/23012475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212025109 |
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