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Hybridization arrest of cell-free translation of the malarial dihydrofolate reductase/thymidylate synthase mRNA by anti-sense oligodeoxyribonucleotides.

In order to inhibit the in vitro translation of Plasmodium falciparum mRNA coding for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS), oligodeoxynucleotides (ODNs) were directed against the translation initiation site or a site in the TS-coding region. In both cases co...

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Библиографические подробности
Главные авторы: Sartorius, C, Franklin, R M
Формат: Artigo
Язык:Inglês
Опубликовано: 1991
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC333923/
https://ncbi.nlm.nih.gov/pubmed/2027768
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