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Poly-N-Acetylglucosamine Fibers Amplify the Effectiveness of Recombinant Factor VIIA on Clot Formation in Hemophilia B Canine Blood

BACKGROUND: Achieving hemostasis in anticoagulated patients is an increasingly important clinical issue. Poly-N-acetylglucosamine (pGlcNAc) nanofibers activate platelets by β(3) subunit (CD61) and the von Willebrand receptor GP1b (CD42b) integrin signaling for generation of a prothrombotic surface m...

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Main Authors: Fischer, Thomas H., Nichols, Timothy C., Scull, Christopher M., Smith, Carr J., Demcheva, Marina
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339183/
https://ncbi.nlm.nih.gov/pubmed/21814114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0b013e31822556f4
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