Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies

Interleukin 21 (IL-21) is a type I four-helical bundle cytokine that exerts a variety of significant effects on many hematopoietic cells, including T and B lymphocytes and natural killer cells. IL-21 is produced predominantly by CD4(+) T cells and natural killer T cells and, when aberrantly overexpr...

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Detalhes bibliográficos
Main Authors: Maurer, Mark F, Garrigues, Ursula, Jaspers, Stephen R, Meengs, Brent, Rixon, Mark W, Stevens, Brenda L, Lewis, Kenneth B, Julien, Susan H, Bukowski, Thomas R, Wolf, Anitra C, Hamacher, Nels B, Snavely, Mark, Dillon, Stacey R
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338942/
https://ncbi.nlm.nih.gov/pubmed/22327431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.4.1.18713
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