Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication

BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends o...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chhatwal, Patrick, Bankwitz, Dorothea, Gentzsch, Juliane, Frentzen, Anne, Schult, Philipp, Lohmann, Volker, Pietschmann, Thomas
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338857/
https://ncbi.nlm.nih.gov/pubmed/22558311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036029
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