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Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis

Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting the host immune response during this disease provides insight as to why brucellosis is often difficult to resolve. We used a Brucella epitope specific in vivo killing assay to investigate the ability...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Durward, Marina, Radhakrishnan, Girish, Harms, Jerome, Bareiss, Claire, Magnani, Diogo, Splitter, Gary A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338818/
https://ncbi.nlm.nih.gov/pubmed/22558103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034925
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