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Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis

Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting the host immune response during this disease provides insight as to why brucellosis is often difficult to resolve. We used a Brucella epitope specific in vivo killing assay to investigate the ability...

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Détails bibliographiques
Auteurs principaux: Durward, Marina, Radhakrishnan, Girish, Harms, Jerome, Bareiss, Claire, Magnani, Diogo, Splitter, Gary A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338818/
https://ncbi.nlm.nih.gov/pubmed/22558103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034925
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