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Why Do Protein Folding Rates Correlate with Metrics of Native Topology?

For almost 15 years, the experimental correlation between protein folding rates and the contact order parameter has been under scrutiny. Here, we use a simple simulation model combined with a native-centric interaction potential to investigate the physical roots of this empirical observation. We sim...

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Autors principals: Faísca, Patrícia F. N., Travasso, Rui D. M., Parisi, Andrea, Rey, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338708/
https://ncbi.nlm.nih.gov/pubmed/22558173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035599
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