PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury

Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is not clear whether PAI-1 plays a role in acute...

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Autori principali: Abderrahmani, Rym, François, Agnes, Buard, Valerie, Tarlet, Georges, Blirando, Karl, Hneino, Mohammad, Vaurijoux, Aurelie, Benderitter, Marc, Sabourin, Jean-Christophe, Milliat, Fabien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338537/
https://ncbi.nlm.nih.gov/pubmed/22563394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035740
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