BACE2 Expression Increases in Human Neurodegenerative Disease

β-Secretase, the rate-limiting enzymatic activity in the production of the amyloid-β (Aβ) peptide, is a major target of Alzheimer's disease (AD) therapeutics. There are two forms of the enzyme: β-site Aβ precursor protein cleaving enzyme (BACE) 1 and BACE2. Although BACE1 increases in late-stag...

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Bibliografiske detaljer
Main Authors: Holler, Christopher J., Webb, Robin L., Laux, Ashley L., Beckett, Tina L., Niedowicz, Dana M., Ahmed, Rachel R., Liu, Yinxing, Simmons, Christopher R., Dowling, Amy L.S., Spinelli, Angela, Khurgel, Moshe, Estus, Steven, Head, Elizabeth, Hersh, Louis B., Murphy, M. Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2012
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338345/
https://ncbi.nlm.nih.gov/pubmed/22074738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.09.034
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