BACE2 Expression Increases in Human Neurodegenerative Disease

β-Secretase, the rate-limiting enzymatic activity in the production of the amyloid-β (Aβ) peptide, is a major target of Alzheimer's disease (AD) therapeutics. There are two forms of the enzyme: β-site Aβ precursor protein cleaving enzyme (BACE) 1 and BACE2. Although BACE1 increases in late-stag...

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Detalhes bibliográficos
Main Authors: Holler, Christopher J., Webb, Robin L., Laux, Ashley L., Beckett, Tina L., Niedowicz, Dana M., Ahmed, Rachel R., Liu, Yinxing, Simmons, Christopher R., Dowling, Amy L.S., Spinelli, Angela, Khurgel, Moshe, Estus, Steven, Head, Elizabeth, Hersh, Louis B., Murphy, M. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338345/
https://ncbi.nlm.nih.gov/pubmed/22074738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.09.034
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