Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

BACKGROUND AND OBJECTIVES: The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. DESIGN, SETTING, PA...

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Bibliografiske detaljer
Main Authors: Bomback, Andrew S., Smith, Richard J., Barile, Gaetano R., Zhang, Yuzhou, Heher, Eliot C., Herlitz, Leal, Stokes, M. Barry, Markowitz, Glen S., D’Agati, Vivette D., Canetta, Pietro A., Radhakrishnan, Jai, Appel, Gerald B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2012
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338285/
https://ncbi.nlm.nih.gov/pubmed/22403278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.12901211
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