Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

BACKGROUND AND OBJECTIVES: The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. DESIGN, SETTING, PA...

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Detalhes bibliográficos
Main Authors: Bomback, Andrew S., Smith, Richard J., Barile, Gaetano R., Zhang, Yuzhou, Heher, Eliot C., Herlitz, Leal, Stokes, M. Barry, Markowitz, Glen S., D’Agati, Vivette D., Canetta, Pietro A., Radhakrishnan, Jai, Appel, Gerald B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338285/
https://ncbi.nlm.nih.gov/pubmed/22403278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.12901211
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