Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

BACKGROUND AND OBJECTIVES: The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. DESIGN, SETTING, PA...

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Detalles Bibliográficos
Autores principales: Bomback, Andrew S., Smith, Richard J., Barile, Gaetano R., Zhang, Yuzhou, Heher, Eliot C., Herlitz, Leal, Stokes, M. Barry, Markowitz, Glen S., D’Agati, Vivette D., Canetta, Pietro A., Radhakrishnan, Jai, Appel, Gerald B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2012
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338285/
https://ncbi.nlm.nih.gov/pubmed/22403278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.12901211
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