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The binding site and mechanism of the RNA polymerase inhibitor tagetitoxin: An issue open to debate

In a recent paper in the Journal of Biological Chemistry, Artsimovitch et al.(2) report a major revision of a crystallographic model and proposed mechanism of the RNA polymerase inhibitor, tagetitoxin. This reassessment is based on theoretical modeling using molecular dynamics simulations. Here, we...

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Bibliografiske detaljer
Main Authors: Klyuyev, Sergiy, Vassylyev, Dmitry G.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337825/
https://ncbi.nlm.nih.gov/pubmed/22414754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.19468
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