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Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase
Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337727/ https://ncbi.nlm.nih.gov/pubmed/22079754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.074 |
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