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Role of Coupled-Dynamics in the Catalytic Activity of Prokaryotic-like Prolyl-tRNA Synthetases

Prolyl-tRNA synthetases (ProRSs) have been shown to activate both cognate and some noncognate amino acids and attach them to specific tRNA(Pro) substrates. For example, alanine, which is smaller than cognate proline, is misactivated by Escherichia coli ProRS. Mischarged Ala-tRNA(Pro) is hydrolyzed b...

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Dettagli Bibliografici
Autori principali: Sanford, Brianne, Cao, Bach, Johnson, James M., Zimmerman, Kurt, Strom, Alexander M., Mueller, Robyn M., Bhattacharyya, Sudeep, Musier-Forsyth, Karin, Hati, Sanchita
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337710/
https://ncbi.nlm.nih.gov/pubmed/22356126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300097g
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