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Oxidative-Mechanical Stress Signals Stem Cell Niche Mediated Lrp5 Osteogenesis in eNOS(−/−) null mice
INTRODUCTION: Calcific aortic valve disease(CAVD) is the most common indication for valve surgery in the USA. This study hypothesizes that calcific aortic valve disease develops secondary to Wnt3a/Lrp5 activation via oxidative-mechanical stress in eNOS null mice. METHODS: eNOS(−/−) mice were tested...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337361/ https://ncbi.nlm.nih.gov/pubmed/22359381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24031 |
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