Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

BACKGROUND: Virus-like particles have been regularly used as an antigen delivery system for a number of Plasmodium peptides or proteins. The present study reports the immunogenicity and protective efficacy of bacterium-like particles (BLPs) generated from Lactococcus lactis and loaded with Plasmodiu...

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Detalhes bibliográficos
Main Authors: Nganou-Makamdop, Krystelle, van Roosmalen, Maarten L, Audouy, Sandrine AL, van Gemert, Geert-Jan, Leenhouts, Kees, Hermsen, Cornelus C, Sauerwein, Robert W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337279/
https://ncbi.nlm.nih.gov/pubmed/22348325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-50
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