Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of spinal cord and optic nerve caused by pathogenic autoantibodies (NMO-IgG) against astrocyte aquaporin-4 (AQP4). We developed a high-throughput screen to identify blockers of NMO-IgG binding to human AQP4 using a human recombinant...

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Autors principals: Tradtrantip, Lukmanee, Zhang, Hua, Anderson, Marc O., Saadoun, Samira, Phuan, Puay-Wah, Papadopoulos, Marios C., Bennett, Jeffrey L., Verkman, A. S.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2012
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336779/
https://ncbi.nlm.nih.gov/pubmed/22319008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-201608
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