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A deimmunized bispecific ligand directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model
OBJECTIVE: The objective was to test a bispecific ligand directed toxin (BLT), with reduced immunogenicity for enhanced efficacy in targeting orthotopic pancreatic cancer in vivo. METHOD: A new BLT was created in which both human EGF and IL-4 cytokines were cloned onto the same single chain molecule...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336038/ https://ncbi.nlm.nih.gov/pubmed/22258068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e31823b5f2e |
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