Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse lung cancer stem-like cells (CSC). Mmp10 is highly expressed in oncosphere cultur...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Justilien, Verline, Regala, Roderick P., Tseng, I-Chu, Walsh, Michael P., Batra, Jyotica, Radisky, Evette S., Murray, Nicole R., Fields, Alan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335833/
https://ncbi.nlm.nih.gov/pubmed/22545096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035040
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