Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse lung cancer stem-like cells (CSC). Mmp10 is highly expressed in oncosphere cultur...

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Hlavní autoři: Justilien, Verline, Regala, Roderick P., Tseng, I-Chu, Walsh, Michael P., Batra, Jyotica, Radisky, Evette S., Murray, Nicole R., Fields, Alan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335833/
https://ncbi.nlm.nih.gov/pubmed/22545096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035040
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