Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha

BACKGROUND: Retinoid X receptor-alpha (RXRα) is a key member of the nuclear receptor superfamily. We recently demonstrated that proteolytic cleavage of RXRα resulted in production of a truncated product, tRXRα, which promotes cancer cell survival by activating phosphatidylinositol-3-OH kinase (PI3K)...

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Main Authors: Lu, Na, Liu, Jinxing, Liu, Jie, Zhang, Chunyun, Jiang, Fuquan, Wu, Hua, Chen, Liqun, Zeng, Wenjun, Cao, Xihua, Yan, Tingdong, Wang, Guanghui, Zhou, Hu, Lin, Bingzhen, Yan, Xiaomei, Zhang, Xiao-kun, Zeng, Jin-Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335786/
https://ncbi.nlm.nih.gov/pubmed/22545132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035722
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