Targeting Truncated Retinoid X Receptor-α by CF31 induces TNFα-dependent apoptosis

A truncated version of retinoid X receptor-α, tRXRα, promotes cancer cell survival by activating the PI3K/AKT pathway. However, targeting the tRXRα-mediated survival pathway for cancer treatment remains to be explored. We report here our identification of a new natural product molecule, CF31, a xant...

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Hlavní autoři: Wang, Guang-hui, Jiang, Fu-quan, Duan, Ying-hui, Zeng, Zhi-ping, Chen, Fan, Dai, Yi, Chen, Jie-bo, Liu, Jinxing, Liu, Jie, Zhou, Hu, Chen, Hai-feng, Zeng, Jin-zhang, Su, Ying, Yao, Xin-sheng, Zhang, Xiao-kun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537848/
https://ncbi.nlm.nih.gov/pubmed/23151904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2038
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