Etiopathogenesis of Insulin Autoimmunity

Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction...

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Bibliographic Details
Main Authors: Kanatsuna, Norio, Papadopoulos, George K., Moustakas, Antonis K., Lenmark, Åke
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335545/
https://ncbi.nlm.nih.gov/pubmed/22567309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/457546
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