MicroRNAs and their isomiRs function cooperatively to target common biological pathways

BACKGROUND: Variants of microRNAs (miRNAs), called isomiRs, are commonly reported in deep-sequencing studies; however, the functional significance of these variants remains controversial. Observational studies show that isomiR patterns are non-random, hinting that these molecules could be regulated...

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Główni autorzy: Cloonan, Nicole, Wani, Shivangi, Xu, Qinying, Gu, Jian, Lea, Kristi, Heater, Sheila, Barbacioru, Catalin, Steptoe, Anita L, Martin, Hilary C, Nourbakhsh, Ehsan, Krishnan, Keerthana, Gardiner, Brooke, Wang, Xiaohui, Nones, Katia, Steen, Jason A, Matigian, Nicholas A, Wood, David L, Kassahn, Karin S, Waddell, Nic, Shepherd, Jill, Lee, Clarence, Ichikawa, Jeff, McKernan, Kevin, Bramlett, Kelli, Kuersten, Scott, Grimmond, Sean M
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2011
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334621/
https://ncbi.nlm.nih.gov/pubmed/22208850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-12-r126
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