Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Ultra-deep targeted sequencing (UDT-Seq) can identify subclonal somatic mutations in tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we target 71 kb of mutational hotspots in 42 cancer genes. We present novel methods enhancing both laboratory workfl...

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Detalhes bibliográficos
Main Authors: Harismendy, Olivier, Schwab, Richard B, Bao, Lei, Olson, Jeff, Rozenzhak, Sophie, Kotsopoulos, Steve K, Pond, Stephanie, Crain, Brian, Chee, Mark S, Messer, Karen, Link, Darren R, Frazer, Kelly A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334619/
https://ncbi.nlm.nih.gov/pubmed/22185227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-12-r124
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