A Novel Rare Variant in SCN1Bb Linked to Brugada Syndrome and SIDS by Combined Modulation of Na(v)1.5 and K(v)4.3 Channel Currents

BACKGROUND: Cardiac sodium channel β-subunit mutations have been associated with several inherited cardiac arrhythmia syndromes. OBJECTIVE: To identify and characterize variations in SCN1Bb associated with Brugada (BrS) and sudden infant death syndromes (SIDS). METHODS AND RESULTS: Patient 1 was a 4...

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Autori principali: Hu, Dan, Barajas-Martínez, Hector, Medeiros-Domingo, Argelia, Crotti, Lia, Veltmann, Christian, Schimpf, Rainer, Urrutia, Janire, Alday, Aintzane, Casis, Oscar, Pfeiffer, Ryan, Burashnikov, Elena, Caceres, Gabriel, Tester, David J., Wolpert, Christian, Borggrefe, Martin, Schwartz, Peter, Ackerman, Michael J., Antzelevitch, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334446/
https://ncbi.nlm.nih.gov/pubmed/22155597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.12.006
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