Diabetes-induced vascular dysfunction involves arginase I

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-arginine and by increasing cell proliferation and collagen formation, which promote vascular fibrosis/stiffening. We have shown that increased arginase expression/activity contribute to vascular endothelial cell (E...

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Hlavní autoři: Romero, Maritza J., Iddings, Jennifer A., Platt, Daniel H., Ali, M. Irfan, Cederbaum, Stephen D., Stepp, David W., Caldwell, Ruth B., Caldwell, Robert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Vascular Biology and Microcirculation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334242/
https://ncbi.nlm.nih.gov/pubmed/22058149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00774.2011
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