Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death

Molecular studies examining the impact of mitochondrial morphology on the mammalian heart have previously focused on dynamin related protein-1 (Drp-1) and mitofusin-2 (Mfn-2), while the role of the other mitofusin isoform, Mfn-1, has remained largely unexplored. In the present study, we report the g...

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Hlavní autoři: Papanicolaou, Kyriakos N., Ngoh, Gladys A., Dabkowski, Erinne R., O'Connell, Kelly A., Ribeiro, Rogerio F., Stanley, William C., Walsh, Kenneth
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Energetics and Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334239/
https://ncbi.nlm.nih.gov/pubmed/22037195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00833.2011
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