p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation

p21-activated kinase 1 (Pak1) is a serine/threonine kinase that activates protein phosphatase 2a, resulting in the dephosphorylation of cardiac proteins and increased myofilament Ca(2+) sensitivity. Emerging evidence indirectly indicates a role for Pak1 in ischemia-reperfusion (I/R), but direct evid...

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Detalhes bibliográficos
Main Authors: Monasky, Michelle M., Taglieri, Domenico M., Patel, Bindiya G., Chernoff, Jonathan, Wolska, Beata M., Ke, Yunbo, Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334232/
https://ncbi.nlm.nih.gov/pubmed/22037191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00612.2011
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