The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

BACKGROUND: Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size of c...

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Autores principales: Jünger, Martin A, Rintelen, Felix, Stocker, Hugo, Wasserman, Jonathan D, Végh, Mátyás, Radimerski, Thomas, Greenberg, Michael E, Hafen, Ernst
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2003
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC333403/
https://ncbi.nlm.nih.gov/pubmed/12908874
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