The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. The mechanisms governing replication of terminally differentiated β cells and neogenesis from progenitor cells are unclear. Mice lacking insulin receptor substrate-2 (Irs2) develop β cell failure...

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Detalhes bibliográficos
Main Authors: Kitamura, Tadahiro, Nakae, Jun, Kitamura, Yukari, Kido, Yoshiaki, Biggs, William H., Wright, Christopher V.E., White, Morris F., Arden, Karen C., Accili, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151657/
https://ncbi.nlm.nih.gov/pubmed/12488434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200216857
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