The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. The mechanisms governing replication of terminally differentiated β cells and neogenesis from progenitor cells are unclear. Mice lacking insulin receptor substrate-2 (Irs2) develop β cell failure...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Kitamura, Tadahiro, Nakae, Jun, Kitamura, Yukari, Kido, Yoshiaki, Biggs, William H., Wright, Christopher V.E., White, Morris F., Arden, Karen C., Accili, Domenico
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2002
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12488434/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI200216857
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