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Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication
DNA topology plays a crucial role in all living cells. In prokaryotes, negative supercoiling is required to initiate replication and either negative or positive supercoiling assists decatenation. The role of DNA knots, however, remains a mystery. Knots are very harmful for cells if not removed effic...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3333868/ https://ncbi.nlm.nih.gov/pubmed/22187153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1237 |
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