Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

When thrombin is added to washed human platelets, one of its actions results in activation of a phospholipase that hydrolyzes arachidonic acid from phospholipids. The arachidonate is converted to the cyclic endoperoxides (prostaglandin G2 and prostaglandin H2) by fatty acid cyclo-oxygenase. These co...

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Bibliographic Details
Main Authors: Minkes, M, Stanford, N, Chi, M M, Roth, G J, Raz, A, Needleman, P, Majerus, P W
Format: Artigo
Language:Inglês
Published: 1977
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC333381/
https://ncbi.nlm.nih.gov/pubmed/190267
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