Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

When thrombin is added to washed human platelets, one of its actions results in activation of a phospholipase that hydrolyzes arachidonic acid from phospholipids. The arachidonate is converted to the cyclic endoperoxides (prostaglandin G2 and prostaglandin H2) by fatty acid cyclo-oxygenase. These co...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Minkes, M, Stanford, N, Chi, M M, Roth, G J, Raz, A, Needleman, P, Majerus, P W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1977
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/190267/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI108659
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