Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs.

Intact sheep antidigoxin antibodies and their Fab fragments have both been found to exert profound effects on digoxin pharmacokinetics in [3H] digoxin-treated dogs. Both classes of molecule remove digoxin from the extravascular space and sequester it in the circulation in protein-bound form, a form...

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Pubblicato in:	J Clin Invest
Autori principali:	Butler, V P, Schmidt, D H, Smith, T W, Haber, E, Raynor, B D, Demartini, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1977
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333366/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/299860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI108647
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