Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs.

Intact sheep antidigoxin antibodies and their Fab fragments have both been found to exert profound effects on digoxin pharmacokinetics in [3H] digoxin-treated dogs. Both classes of molecule remove digoxin from the extravascular space and sequester it in the circulation in protein-bound form, a form...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Butler, V P, Schmidt, D H, Smith, T W, Haber, E, Raynor, B D, Demartini, P
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1977
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333366/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/299860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI108647
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