Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs.

Intact sheep antidigoxin antibodies and their Fab fragments have both been found to exert profound effects on digoxin pharmacokinetics in [3H] digoxin-treated dogs. Both classes of molecule remove digoxin from the extravascular space and sequester it in the circulation in protein-bound form, a form...

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Autors principals: Butler, V P, Schmidt, D H, Smith, T W, Haber, E, Raynor, B D, Demartini, P
Format: Artigo
Idioma:Inglês
Publicat: 1977
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC333366/
https://ncbi.nlm.nih.gov/pubmed/299860
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