Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia

We characterized leukemia stem cells (LSC) in chronic phase chronic myelogenous leukemia (CML) using a transgenic mouse model. LSC were restricted to cells with long-term hematopoietic stem cell (LTHSC) phenotype. CML LTHSC demonstrated reduced homing and retention in the bone marrow (BM), related t...

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Autors principals: Zhang, Bin, Ho, Yin Wei, Huang, Qin, Maeda, Takahiro, Lin, Allen, Lee, Sung-uk, Hair, Alan, Holyoake, Tessa L., Huettner, Claudia, Bhatia, Ravi
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332001/
https://ncbi.nlm.nih.gov/pubmed/22516264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.018
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