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The SMAC mimetic RMT5265.2HCL induces apoptosis in EBV AND HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac

The inhibitors of apoptosis (IAP) are important regulators of apoptosis. However, little is known about the capacity of Smac mimetics (IAP inhibitor) to overcome virally-associated-lymphoma’s (VAL) resistance to apoptosis. Here, we explored the pro-apoptotic effect of a novel Smac mimetic, RMT5265.2...

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Detalhes bibliográficos
Main Authors: Ramachandiran, Sampath, Cain, Joan, Liao, Albert, He, Yanjuan, Guo, Xiangxue, Boise, Lawrence H., Fu, Haian, Ratner, Lee, Khoury, Hanna Jean, Bernal-Mizrachi, Leon
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331941/
https://ncbi.nlm.nih.gov/pubmed/22325366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.12.024
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