Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice

T cell-mediated rejection remains a barrier to the clinical application of islet xenotransplantation. Regulatory T cells (Treg) regulate immune responses by suppressing effector T cells. This study aimed to determine the ability of human Treg to prevent islet xenograft rejection and the mechanism(s)...

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Hlavní autoři: Yi, Shounan, Ji, Ming, Wu, Jingjing, Ma, Xiaoqian, Phillips, Peta, Hawthorne, Wayne J., O’Connell, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331767/
https://ncbi.nlm.nih.gov/pubmed/22403295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1306
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