Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the Kras(G12D) Mouse Model

Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and columnar cell atypia resembling low-grade Pan...

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Hlavní autoři: Gier, Belinda, Matveyenko, Aleksey V., Kirakossian, David, Dawson, David, Dry, Sarah M., Butler, Peter C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Pharmacology and Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331736/
https://ncbi.nlm.nih.gov/pubmed/22266668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1109
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