Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the Kras(G12D) Mouse Model

Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and columnar cell atypia resembling low-grade Pan...

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Detalhes bibliográficos
Main Authors: Gier, Belinda, Matveyenko, Aleksey V., Kirakossian, David, Dawson, David, Dry, Sarah M., Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331736/
https://ncbi.nlm.nih.gov/pubmed/22266668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1109
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