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Trafficking and Proteolytic Processing of APP
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from a large type I trans-membrane protein, the β-amyloid precursor protein. The proteolytic enzymes involved in its proce...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3331683/ https://ncbi.nlm.nih.gov/pubmed/22553493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006270 |
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