The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+)

The NAD(+)-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as nutrient restriction. Previous reports have implicated fluctuations in intracellular NAD(+) concentrations as the...

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Main Authors: Gerhart-Hines, Zachary, Dominy, John E., Blättler, Sharon M., Jedrychowski, Mark P., Banks, Alexander S., Lim, Ji-Hong, Chim, Helen, Gygi, Steven P., Puigserver, Pere
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331675/
https://ncbi.nlm.nih.gov/pubmed/22195961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.005
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