11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries

Arachidonic acid is metabolized to four regioisomeric epoxyeicosatrienoic acids (EETs) by cytochrome P-450. 5,6-, 8,9-, 11,12-, and 14,15-EET are equipotent in relaxing bovine coronary arteries (BCAs). Vasorelaxant effects of EETs are nonselectively antagonized by 14,15-epoxyeicosa-5(Z)-enoic acid....

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Autors principals: Bukhari, Ishfaq A., Shah, Abdul Jabbar, Gauthier, Kathryn M., Walsh, Katherine A., Koduru, Sreenivasulu Reddy, Imig, John D., Falck, John R., Campbell, William B.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Vascular Biology and Microcirculation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330801/
https://ncbi.nlm.nih.gov/pubmed/22307677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01122.2011
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